When used as adjunctive therapy with the mood stabilizers lithium or valproate, the schizophrenia drug lumateperone 42 mg improved depressive symptoms in patients with bipolar depression experiencing major depressive episodes, Intra-Cellular…
Robert M. Post, MD, discusses the need for early intervention in bipolar disorder, steps which should be taken after a patient’s first manic episode, and factors to consider when choosing a mood stabilizer for a patient with bipolar disorder.
Alkermes plc is expanding its New Drug Application (NDA) for the investigational drug ALKS 3831—a combination of the antipsychotic olanzapine and the novel molecular entity samidorphan—to include the treatment of bipolar I disorder as well as schizophrenia, the drugmaker recently announced.
Lumateperone, an investigational drug from Intra-Cellular Therapies, Inc., posted varied results in two phase 3 clinical trials evaluating it as a monotherapy for major depressive episodes associated with bipolar disorder.
SAN FRANCISCO—The antipsychotic cariprazine was effective in improving depressive symptoms in patients with bipolar depression and concurrent manic symptoms, according to a poster presented at the American Psychiatric Association’s annual meeting.