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Psych Congress  

Assessing the burden of treatment-emergent adverse events associated with atypical antipsychotic medications (AAPs) in Major Depressive Disorder (MDD): The Patient Perspective

Authors  
Ann Hartry, PhD
Clément François, PhD
Pierre Michel Llorca, MD, PhD
Christophe Lançon, MD, PhD
Dana DiBenedetti, PhD
Michelle Brown, PhD
Sponsor  
Lundbeck, LLC

Background: Patients with MDD experience a wide range of adverse events [AEs] associated with their treatment. This qualitative study explored the perceived burden of AEs associated with AAPs among patients with MDD. Methods: Utilizing both spontaneous and probed recall, a comprehensive listing of AEs associated with AAPs was elicited in focus groups with patients with MDD. Patients were asked to list AEs they associate with AAPs and describe the frequency and burden of each. Because patients may not be fully aware of certain adverse events, a focus group was conducted with 4 psychiatrists to gather feedback on the AEs associated with AAPs and the patient-perceived bother of each. Results: 25 patients with MDD participated with a mean age of 46.4 years (64 % female). Patients were most likely to independently list cognitive issues, weight gain, somnolence, and low energy level. These were also ranked as "most bothersome" AEs by 52%, 32%, 28%, and 28% of patients, respectively. All 4 psychiatrists identified weight gain as both clinically important and "most bothersome" to patients. Psychiatrists also rated sexual dysfunction, EPS, and akathisia as most bothersome to patients, but were slightly less likely to endorse cognition, somnolence or low energy as among the most bothersome AEs to patients. Conclusions: The AE of weight gain garnered agreement between patients and physicians as bothersome. Interestingly, however, cognitive issues, sedation, and low energy were reported as very bothersome by patients but to a much lesser extent by physicians.

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