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Psych Congress  

Depressive Symptoms and Their Impact on Functioning and Overall Well-Being from a Patient's Perspective

Jyotsna Mehta, B.Pharm, MS; Xiaowu Sun, PhD; Asli Memisoglu, MS, ScD; Arielle Stanford, MD; Nikki Levy, BS; Mugdha Gore, B.Pharm, PhD

This poster was presented at the 30th annual  Psych Congress, held Sept. 16-19, 2017, in New Orleans, Louisiana.

Background: Depression severity is most commonly assessed using clinician-rated instruments. The extent to which these scales capture the patient's experience of depression is unclear. Understanding patients' perspectives on the importance of depressive symptoms and their effect on overall well-being might lead to improved outcomes.

Methods: Subjects with major depressive disorder (MDD) who participated in a long-term safety and tolerability study of ALKS 5461 (NCT 02141399) for _3 months completed a survey at their last study visit. Subjects rank ordered the importance of symptoms captured in the 10-item Montgomery-Ѓsberg Depression Rating Scale (MADRS-10), rated the impact of depression on daily functioning (daily activities, social life, family life; [1=None to 10=Extreme]) and their overall well-being (0=Not Well to 10=Very Well). Correlations between MADRS-10 score at the last study visit and daily functioning and overall well-being responses were assessed.

Results: A total of 123 subjects (75% age <55 years, 63% female) completed the survey and had a mean MADRS-10 score of 12.1(9.5). "Sadness", "inability to feel", and "concentration difficulties" were ranked as the most important MADRS symptoms. Mean (SD) scores for impact on daily activities, social life, and family life were 4.0 (3.1), 4.5 (3.2), and 4.2 (3.1), respectively and overall well-being was 5.8 (2.8). Correlations between depression impact on daily functioning and overall well-being with MADRS-10 score were all r >0.3 (P<0.001).

Conclusions: Depression symptoms have a significant impact on daily functioning and overall well-being. Clinicians may consider tailoring individual treatment to address symptoms most concerning to patients.

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