Objective: The goal of this retrospective database analysis was to determine whether quantitative, serial assessment of hyperactivity, impulsivity and inattention using the Quotient ADHD Test could improve the rate of normalization of patients with ADHD compared to community care benchmarks reported in the MTA study. Method: The Quotient ADHD Test measures a subject’s ability to control motor activity, sustain attention and inhibit impulsive responses within developmentally appropriate expectations. Motion and Attention Scaled Scores were analyzed for 1,112 patients with a baseline test (i.e., no medication) plus at least 2 additional serial tests. Results: Outcomes were calculated as the percent change in Scaled Scores for successive tests using three thresholds for improvement: Any Improvement (Scaled Score reduction), >25% Improvement (moderate improvement) or >40% improvement (robust improvement). The Attention Scaled Scores improved by at least 40% in 35% of patient at Test #3. The Motion Scaled Scores improved by at least 40% in 49% of patients at Test #3. Conclusions: If 40% improvement in Quotient Scaled Scores reflects normalization, these results suggest that using quantitative data to guide treatment decisions improved outcomes compared to the MTA community care cohort, where 25% of patients were deemed normalized. It is feasible and practical to implement the Quotient ADHD Test for the objective measurement of hyperactivity, impulsivity and inattention as an aid in the diagnosis and ongoing management of ADHD in a community care setting.
Daniel Hartman, MD. Carrie Mulherin, MBA. Henry Hasson, MD. Kevin Horvath, MD.