Objective: To investigate the association between opioid drug use and cardiometabolic risk factors (CDRF) in adults using Nutrition Examination Survey (NHANES) data.
Methods: A retrospective cross-sectional analysis was performed using the 2009-2018 NHANES data, with a total sample size (N) of 10,032 eligible participants. The data were analyzed to study the relationship between opioid drug use (four groups: drug use (DU), illicit drug use (IDU), repeated drug use (RDU), and current drug use (CDU)) and CDRF (i.e., hypertension, abnormal triglyceride levels, low-level of high-density lipoproteins, high waist circumference, insulin resistance, serum cotinine levels, higher C-reactive protein, hypercholesterolemia, and increased body mass index). The statistical correlation was evaluated using the chi-square analysis, p-value < 0.05 considered as statistically significant.
Results: The analysis found males were more likely than females (p‚â§0.001) to have ever reported using drugs at least once in their lifetime. In fact, males were more likely than females to report ever using cocaine (p=0.01), heroin (p=0.01), and marijuana (p = 0.01). Additionally, males were significantly more likely than females to disclose the current use of illicit drugs (p=0.002), and have consumed more with at least 12 alcoholic beverages per year (p<0.001). Overall, we found no association between substance use and having a cluster of three or more CDRF variables for both males and females.
Conclusion: Study results highlight the prevalence of gender differences in DU and its reporting. With the rising popularity of illicit drugs, clinicians must be aware of its association with CDRF.