Depression

Models that used coded clinical data from electronic health records predicted antidepressant treatment response in general but not response to specific antidepressants in patients with major depressive disorder.

Ongoing or worsening sleep difficulties in older adults with depression may signal increased risk of continued depression and suicidal ideation, according to a study published online in Sleep. 

People with low mood and a history of depression tend not to use mood-modifying activities to stabilize mood, according to research published online in JAMA Psychiatry.

Depression is “vastly underdiagnosed” in people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), states a literature review published online in the Harvard Review of Psychiatry.

The protein GPR56 may provide an easy-to-measure biomarker of a patient’s response to antidepressants as well as a novel drug target for the treatment of major depressive disorder, according to a published study.

Women who had depressive symptoms during their third trimester of pregnancy, or persistently before and after giving birth, were twice as likely to have babies with very low levels of immunoglobulin A.

    AXS-05, an investigational modulated-delivery tablet, significantly improved symptoms of depression

Researchers have developed a machine learning algorithm that uses electroencephalogram (EEG) data to predict whether a selective serotonin reuptake inhibitor (SSRI) is likely to benefit a patient.

Patients with residual depressive symptoms who received online mindfulness-based cognitive therapy (MBCT) plus usual care demonstrated significant gains in depression and functional outcomes, compared with patients who received usual care only.

A single dose of psilocybin combined with psychotherapy produced significant improvements in emotional and existential distress in patients with cancer that lasted more than 4 years, according to a published study.